| Runda | Tor | Data | Kierowca | Pojazd | Zespół |
|---|---|---|---|---|---|
| 1 |  Salò Garda Circuit | 1921.05.22 | Bugatti T22 | Eugenio Silvani | |
| 2 | Madonie Targa Florio | 1921.05.29 | FIAT 451 | Giulio Masetti | |
| 3 |  Indianapolis Indianapolis 500 | 1921.05.30 | Frontenac |  | |
| 4 | Florence Coppa della Cascine | 1921.06.06 | Chiribiri | | |
| 5 | Mugello Mugello Circuit | 1921.07.24 | Alfa Romeo 40/60 | ALFA-Romeo | |
| 6 | Brescia Grand Prix Włoch | 1921.09.04 | Ballot 3L - Ballot |  Ballot | |
| 7 | Brescia Coppa Florio | 1921.09.04 | Ballot 3L - Ballot | Ballot | |
| 8 | Brescia Gentlemen Grand Prix | 1921.09.11 | Mercedes-Benz 18/100 | Giulio Masetti | |
| 9 | Montenero Coppa Montenero | 1921.09.25 | Ansaldo 2000 | |